Recent Methodological Advances in Genome-Wide Association Studies

Wed, Aug 7, 10:30 AM - 12:20 PM

Siyuan ChenChair

Section on Statistics in Genomics and Genetics

7 Presentations

A knockoff framework for the identification of putative causal variants in GWAS with trio design

10:35 AM - 10:50 AM

Yi Yang (City University of Hong Kong)

Co-authors: Chen Wang (Columbia University), Linxi Liu (Univeristy of Pittsburgh), Joseph Buxbaum (Icahn School of Medicine at Mount Sinai), Zihuai He (Stanford University), Iuliana Ionita-Laza (Columbia University)

Efficient heritability enrichment analysis with graphREML

10:50 AM - 11:05 AM

Hui Li (Harvard University School of Public Health)

Co-authors: Rahul Mazumder (Massachusetts Institute of Technology), Luke O'Connor (Harvard Medical School), Xihong Lin (Harvard T.H. Chan School of Public Health)

Heritability estimation using genetic similarity embedding

11:05 AM - 11:20 AM

Jianqiao Wang

Knockoff-Based Statistics for the Identification of Putative Causal Genes in Genetic Studies

11:20 AM - 11:35 AM

Shiyang Ma (Shanghai Jiao Tong University)

Co-authors: Zihuai He (Stanford University), Iuliana Ionita-Laza (Columbia University)

Multi-organ imaging-derived polygenic indexes for brain and body health

11:35 AM - 11:50 AM

Xiaochen Yang (Purdue University)

Co-authors: Bingxuan Li (University of California, Los Angeles), Zirui Fan, Dezheng Ding (University of Pennsylvania), Juan Shu (Purdue University), Marylyn Ritchie (University of Pennsylvania), Gideon Nave (University of Pennsylvania), Michael Platt (University of Pennsylvania), Tengfei Li (University of North Carolina - Chapel Hill), Hongtu Zhu, Bingxin Zhao

Polygenic risk vectors (PRV) improve genetic risk stratification of diseases

11:50 AM - 12:05 PM

Ruowang Li (Cedars-Sinai Medical Center)

Co-authors: Wanling Xie (Cedars Sinai), Yong Chen (University of Pennsylvania, Perelman School of Medicine), Marylyn Ritchie (University of Pennsylvania), Jason Moore (Cedars-Sinai Medical Center)

Rare-variant studies: When are aggregation tests more powerful than single-variant tests?

12:05 PM - 12:20 PM

Debraj Bose

Co-authors: Christian Fuchsberger (Institute for Biomedicine, Eurac Research, Bolzano, Italy), Michael Boehnke (Univ of Michigan-Ann Arbor)