Statistical Innovation in Oncology Drug Development

Wed, Aug 7, 10:30 AM - 12:20 PM

JIANJUN GANChair

Biopharmaceutical Section

7 Presentations

A New Scoring Method for Ordering Components within the Composite Endpoint in Oncology Trials

10:35 AM - 10:50 AM

Peiwen Yu (University at Albany)

Co-authors: Ling Shi (UMass Boston, Department of Nursing), Edward Valachovic (University at Albany), Victoria Lazariu (University at Albany)

A Novel R Shiny Tool TVCurve for Survival Analysis with Time-Varying Covariate in Oncology Studies

10:50 AM - 11:05 AM

Qian Wu (Fred Hutch)

Co-authors: Yimei Li (University of Pennsylvania), Yang Qiao (Iowa State University), Fei Gao (Fred Hutchinson Cancer Research Center), Jordan Gauthier (Fred Hutch), Qiang Zhang (Wills Eye Hospital), Jarcy Zee (University of Pennsylvania)

A Proof-of-Concept Clinical Trial Design for Evolutionary Guided Precision Medicine for Cancer

11:05 AM - 11:20 AM

Deepak Parashar (University of Warwick)

Co-authors: Wei He (Georgetown University), Peter Mon (Purdue University), Matthew McCoy (Georgetown University), Chen-Hsiang Yeang (Academia Sinica, Teipei), Robert Beckman (Georgetown University)

Adjusting for Multiple Treatment Switching - Stratified Two-stage Method using G-estimation

11:20 AM - 11:35 AM

Luoying Yang

Co-authors: Debarghya Nandi (University of Illinois At Chicago)

Bias in the IPCW estimator for censored pairwise comparisons: the importance of explicit estimands

11:35 AM - 11:50 AM

Taku Chikamochi (Tokyo University of Science)

Co-authors: Musashi Fukuda, Tomohiro Shinozaki (Tokyo University of Science)

Impact of informative censoring in randomized trials with delayed treatment effect

11:50 AM - 12:05 PM

Jingyi Lin (Merck & Co., Inc)

Co-authors: Yujie Zhao (Merck & Co., Inc.), Gregory Chen (Merck & Co., Inc.), Margarita DONICA (Merck & Co., Inc.), Larry León (Merck & Co., Inc.), Ludovic Trinquart (Tufts Medical Center), Sabrina Wan (Merck & Co., Inc.)

Predict PFS and OS using ORR for PD1/PDL1 combination therapy development

12:05 PM - 12:20 PM

Lei Yang (Sanofi US)