Statistical Innovation in Clinical Trial Designs

Wed, Aug 7, 8:30 AM - 10:20 AM

Huihua LiChair

Biopharmaceutical Section

6 Presentations

Bayesian Adaptive Platform Designs via Particle Swarm Optimization

8:35 AM - 8:50 AM

Xinying Fang (Penn State University)

Co-authors: Shouhao Zhou (Penn State University), J. Jack Lee (University of Texas, MD Anderson Cancer Center)

Direct versus stratified covariate adjustment in continuous outcome adaptive randomization for randomized controlled trials

8:50 AM - 9:05 AM

Vahan Aslanyan

Co-authors: Trevor Pickering (Department of Population and Public Health Sciences, University of Southern California), Michelle Nuno, Lindsay Renfro (Children's Oncology Group, Monrovia, CA), Judy Pa (Alzheimer's Disease Cooperative Study (ADCS), Department of Neurosciences, UCSD), Wendy Mack (University of Southern California)

Innovation in Pediatric Trial Design: Balancing Bioethics and the Need for Clinical Data

9:05 AM - 9:20 AM

Sarah O'Connor (Eli Lilly and Company)

Group sequential multi-arm multi-stage trial design with treatment selection

9:20 AM - 9:35 AM

Jianrong Wu (University of New Mexico, Dept. of Internal Medicine)

Co-authors: Yimei Li, Liang Zhu (St. Jude Children's Research Hospital)

Information Growth of Censoring-Robust Estimators in Adaptive Randomization Group Sequential Trials

9:35 AM - 9:50 AM

Navneet Hakhu (University of California-Irvine)

Co-authors: Daniel Gillen (University of California-Irvine)

INFORMATIVE FUTILITY RULES BASED ON CONDITIONAL ASSURANCE

9:50 AM - 10:05 AM

Vladimir Dragalin (Johnson & Johnson)