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Topic-Contributed Paper Session

Advances in Multi-State Model Application in Clinical Trials

Thu, Aug 8, 8:30 AM - 10:20 AM

Wei ZhongOrganizerJoseph CappelleriChair

Biopharmaceutical Section

5 Presentations

Dynamic Assessment of Patient-Reported Outcomes: Unraveling Heterogeneity with Mixture Models and Multi-State Models

8:35 AM - 8:55 AM

Xiaofeng Wang (The Cleveland Clinic Foundation)

Co-authors: Bin Wang (FDA)

Multistate and Joint Longitudinal TGI - Multistate Models for long term OS predictions given limited and immature early phase data only

8:55 AM - 9:15 AM

Ulrich Beyer (F. Hoffmann-La Roche)

WITHDRAWN Informing multistate modeling using an exploratory multivariate hidden Markov approach

9:15 AM - 9:35 AM

Hak-sing Ip (Wake Forest School of Medicine)

Adaptively Weighting Nonfatal Events in Survival Data for Predicting Treatment Effect Relevant to Overall Survival

9:35 AM - 9:55 AM

Qianmiao Gao (FDA)

Synthesis of Multiple Endpoints by Bayesian Multi-state Modeling in Oncology Clinical Trials

9:55 AM - 10:15 AM

Wei Zhong (BioNTech SE)

Co-authors: Yunshan Duan, Xiaohan Guo (Pfizer Inc.)

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