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Contributed Papers

Adaptive Design Applications in Clinical Trials

Tue, Aug 8, 10:30 AM

F. Isik KarahanogluChair

Biopharmaceutical Section

7 Presentations

A Bayesian adaptive Phase II Clinical Trial Design for Radiotherapies with Competing Risk Outcomes

10:35 AM - 10:50 AM

Jina Park (Yonsei University)

Adaptive Multi-arm Multi-stage Designs: a comparison of methods

10:50 AM - 11:05 AM

Cyrus Mehta (Cytel)

Co-authors: Martin Kappler (Cytel)

Adaptive sample size increase for non-parametric tests based on the Mann-Whitney parameter

11:05 AM - 11:20 AM

Thomas Brechenmacher (Cytel Inc)

Designing Sequential Platform Trials

11:20 AM - 11:35 AM

Byron Gajewski (University of Kansas Medical Center)

Co-authors: Alexandra Brown (State of Kansas), Kim Kimminau (University of Missouri), Gillian Bartlett-Esquilant (University of Missouri), Richard Barohn (University of Missouri)

Generalized Conditional Power for Correlated Mixed-type Primary Endpoints

11:35 AM - 11:50 AM

Zejiang Yang (Syneos Health)

Seamless Adaptive Designs of Late-Stage Oncology Clinical Trials with Dose Selection

11:50 AM - 12:05 PM

Co-authors: Sasha Kravets

The extension of 2-in-1 adaptive phase 2/3 designs and its application in oncology clinical trials

12:05 PM - 12:20 PM

Li Fan (Merck & Co., Inc.)

Co-authors: Jing Zhao (Merck Research Laboratories)

Session participants

Elena Polverejan (Johnson & Johnson-Janssen R&D)

Participant

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