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CC = Walter E. Washington Convention Center   M = Marriott Marquis Washington, DC
* = applied session       ! = JSM meeting theme

Activity Details

410 * ! Wed, 8/10/2022, 10:30 AM - 12:20 PM CC-154A
Bayesian Adaptive Designs and Novel Strategies for Dose Optimization in Cellular Therapy Drug Development — Topic Contributed Papers
Biopharmaceutical Section, International Society for Bayesian Analysis (ISBA), Stats. Partnerships Among Academe Indust. & Govt. Committee
Organizer(s): Yunqi Zhao, Takeda Pharmaceutical
Chair(s): Yunqi Zhao, Takeda Pharmaceutical
10:35 AM The Ji3+3 Design for Cell/Gene Therapy Dose-Finding Trials with Joint Efficacy and Toxicity Outcomes
Yuan Ji, The University of Chicago; Xiaolei Lin, Fudan University
10:55 AM PMED: Optimal Bayesian Design for Platform Trials with Multiple Endpoints
Rachael Liu, Takeda Pharamaceuticals; Tian He, Indiana University Purdue University Indianapolis; Meizi Liu, Takeda pharmaceuticals; Jianchang Lin, Takeda Pharmaceuticals
11:15 AM A Sequential Basket Trial Design Based on Multi-Source Exchangeability with Predictive Probability Monitoring
Alexander Kaizer, University of Colorado Anschutz Medical Campus; Emily Zabor, Cleveland Clinic; Lei Nie, U. S. FDA; Brian P Hobbs, The University of Texas
11:35 AM GBOIN-ET: A Generalized Bayesian Optimal Interval Design for Optimal Dose-Finding Accounting for Ordinal Graded Efficacy and Toxicity in Early Clinical Trials
Kentaro Takeda, Astellas Pharma Global Development, Inc.
11:55 AM Discussant: Shuqi Wang, Georgetown University
12:15 PM Floor Discussion
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