Conference Program Home
  My Program

All Times EDT

Legend:
* = applied session       ! = JSM meeting theme

Activity Details

135 * ! Mon, 8/8/2022, 10:30 AM - 12:20 PM CC-203AB
The Use of Baseline Covariates and Early Read-Outs in Adaptive and Group Sequential Designs: Worth the Effort? — Topic Contributed Papers
Biopharmaceutical Section
Organizer(s): Lisa Hampson, Novartis Pharma AG, Switzerland; Kelly Van Lancker, Johns Hopkins University, Bloomberg School of Public Health, US and Ghent University, Belgium
Chair(s): Lisa Hampson, Novartis Pharma AG, Switzerland
10:35 AM Combining Covariate Adjustment with Group Sequential and Information Adaptive Designs to Improve Randomized Trial Efficiency
Kelly Van Lancker, Johns Hopkins University, Bloomberg School of Public Health, US and Ghent University, Belgium; Joshua Betz, Johns Hopkins Bloomberg School of Public Health; Michael Rosenblum, Johns Hopkins Bloomberg School of Public Health
10:55 AM Using a Combination of Early and Primary Endpoint Data in Group-Sequential and Interrupted Clinical Trials
Nigel Stallard, University of Warwick
11:15 AM Use of Short-Term Outcomes in Adaptive Seamless Designs with Treatment or Subgroup Selection
Tim Friede, University Medical Center Goettingen
11:35 AM MIRROS: Planning a Phase 3 Trial with Time-to-Event Endpoint, a Cure Proportion, and a Futility Interim Analysis Using Response
Kaspar Rufibach, F. Hoffmann-La Roche; Dominik Heinzmann, F. Hoffmann-La Roche; Annabelle Monnet, F. Hoffmann-La Roche
11:55 AM Joint Modeling of Longitudinal and Time-to-Event Data Applied to Adaptive Clinical Trials
Abigail Burdon, University of Cambridge
12:15 PM Floor Discussion