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Activity Number: 559 - Spectral Analysis, Process Monitoring, and Sampling
Type: Contributed
Date/Time: Thursday, August 11, 2022 : 10:30 AM to 12:20 PM
Sponsor: Section on Physical and Engineering Sciences
Abstract #323629
Title: Assessing Similarity of Raman Spectra
Author(s): Hacene Boukari* and Yahira Lopez and Mohamed Salih and Fatima Boukari and Cleon Barnett and Jobayer Hossain
Companies: Delaware State University and Delaware State University and Delaware State University and Delaware State University and Alabama State University and Nemours Children's Health
Keywords: Raman Spectroscopy; Intensity Correlation Analysis; Ficoll; crowding; chemometric
Abstract:

Raman inelastic scattering is associated with distinctive vibrational modes of a molecule. Measured Raman spectrum provides information about the bonds and molecular structures. Continuous efforts have been focused on developing novel data processing to extract accurate and relevant information from raw spectra. Here, we report results of intensity correlation analysis (ICA) of Raman spectra of Ficoll and Alginate samples prepared at different concentrations. While both Ficoll and Alginate are polysaccharide, their molecular structures are different -branched and linear. Their spectra display complex set of peaks attributed to the vibrational modes of Ficoll and Alginate molecules, water molecules, and oxygen and nitrogen molecules. For Ficoll solutions, ICA shows an overall linear trend, indicating similarity of the spectra. At high concentration (~1000 mg/ml) ICA shows a closed loop, due to shift of certain peaks. Comparison of Alginate and Ficoll spectra show significant differences in the 800-1500 cm-1 range but similar patterns at wavenumber large 1500 cm-1. The results demonstrate ICA as a potential insightful tool in chemometrics analysis of crowded biological samples.


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