Conference Program Home
  My Program

All Times EDT

Abstract Details

Activity Number: 243 - Operational Considerations in Clinical Trials
Type: Contributed
Date/Time: Tuesday, August 9, 2022 : 8:30 AM to 10:20 AM
Sponsor: Biopharmaceutical Section
Abstract #323126
Title: Power and Sample Size Calculation for Weighted Log-Rank Tests in Group Sequential Trials
Author(s): Kaifeng Lu*
Companies: BeiGene
Keywords: group sequential; non-proportional hazards; weighted log-rank test; information fraction; error spending function
Abstract:

Weighted log-rank tests can be more powerful than the conventional log-rank test for detecting the treatment effect in the presence of non-proportional hazards. We demonstrate how the critical values and futility boundaries can be calculated for weighted log-rank tests in group sequential trials when the error spending functions are given. We differentiate between event fractions and information fractions for weighted log-rank tests and discuss the implications for both analytic calculations and simulation studies.


Authors who are presenting talks have a * after their name.

Back to the full JSM 2022 program