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Activity Number:
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116
- Epidemiological Models for Longitudinal Studies, Time-to-Event Outcomes, and Functional Data
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Type:
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Contributed
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Date/Time:
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Monday, August 8, 2022 : 8:30 AM to 10:20 AM
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Sponsor:
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Section on Statistics in Epidemiology
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Abstract #322287
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Title:
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Kidney Disease and Mortality in Type 2 Diabetes: Applying Multistate Models with Time-Varying Transitions and Joint Models for Longitudinal and Multistate Processes
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Author(s):
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Elsa Vazquez Arreola* and Andrew C Wills and William C Knowler and Robert L Hanson
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Companies:
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National Institute of Diabetes and Digestive and Kidney Diseases and National Institute of Diabetes and Digestive and Kidney Diseases and National Institute of Diabetes and Digestive and Kidney Diseases and National Institute of Diabetes and Digestive and Kidney Diseases
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Keywords:
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longitudinal data;
Survival outcomes;
linear mixed models;
joint models
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Abstract:
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High albumin to creatinine ratio (ACR) and low estimated glomerular filtration rate (eGFR) are biomarkers of kidney disease that are associated with increased risk of cardiovascular disease (CVD) and all-cause mortality in persons with type 2 diabetes (T2D). The Look AHEAD randomized clinical trial in adults with T2D measured ACR and eGFR longitudinally and followed subjects for time to fatal and non-fatal CVD events and to all-cause mortality. We use multistate models with time-varying transitions and joint models for longitudinal and multistate processes to study time-dependent associations of ACR and eGFR with these events. We explore the time-dependent associations of ACR and eGFR with the transitions from baseline state to non-fatal CVD events, from baseline state to all-cause mortality and from non-fatal CVD events to all-cause mortality. The first non-fatal CVD event during the trial is an intermediate event between the baseline state and mortality because its occurrence may affect values of ACR and/or eGFR. We discuss differences in estimation approaches between the two models and compare the estimates of the time-dependent associations obtained and the conclusions reached.
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Authors who are presenting talks have a * after their name.
