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Activity Number: 374 - Bayesian Clinical Trial Designs with Heterogeneous Patient Subgroups
Type: Topic Contributed
Date/Time: Wednesday, August 10, 2022 : 8:30 AM to 10:20 AM
Sponsor: Biopharmaceutical Section
Abstract #320929
Title: Dose Finding with Heterogeneous Patient Subgroups
Author(s): ANASTASIA IVANOVA* and Pooja Saha
Companies: UNC at Chapel Hill and Center for Biostatistics in AIDS Research, Department of Biostatistics, Harvard T.H. Chan
Keywords: Subgroups; CRM; POCRM

In a dose-finding trial with heterogeneous subgroups, it can be unclear how to order responses to new therapy across subgroups and dose levels. We extend the partial order CRM (POCRM) for use with a continuous outcome through the quasi-Bernoulli likelihood. We show how to use the POCRM to find the recommended phase 2 dose defined as the dose with mean response equal to a pre-specified value of a continuous response biomarker.

Authors who are presenting talks have a * after their name.

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