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Abstract:
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Diagnosis and treatment of human diseases require joint interpretation of molecular variations at multiple levels. For example, while the human microbiome has been proved associated with host health, limited knowledge is known about the underlying mechanism of these associations. One potential mechanism is microbial metabolism, which may affect host metabolic processes. Thus, an integrative analysis of microbiome, metabolome, and host health may shed light on the biological mechanism of microbiome-host interactions. However, this analysis is challenging because it involves multiple high-dimensional data sets and complex correlations between microbes, between metabolites, and between a microbe and a metabolite. We propose a high-dimensional data integration tool based on the joint matrix decomposition (called JMDR) to examine joint associations between multi-omics data and an outcome of interest. The JMDR is able to examine the global joint effects on the outcome as well as the contributions each biomarker makes to the joint effects. Thus, the JMDR facilitates the understanding of the interplay between the multi-omics variations and human health.
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