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Activity Number:
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123
- The Early Bird Catches the Worm: Sequential Decision-Making as a Framework in Time of COVID-19 Pandemic
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Type:
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Invited
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Date/Time:
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Monday, August 8, 2022 : 10:30 AM to 12:20 PM
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Sponsor:
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Caucus for Women in Statistics
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Abstract #320520
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Title:
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A Sequential Test of Treatment Effects Under Staggered Entry in a Multi-Center Clinical Trial
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Author(s):
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Sung-Min Han and Dong-Yun Kim*
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Companies:
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i2KIE LLC and NHLBI/NIH
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Keywords:
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clinical trial;
sequential test;
survival time;
staggered entry
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Abstract:
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In this talk we present a new test that compares the treatment effects on survival time when patients enroll following a Poisson process in a multi-center clinical trial. Based on the nonlinear renewal theory, the fully sequential test utilizes the patient entry times for updating the test statistic. We illustrate the method using real-world datasets including chronic granulomatous disease (CGD) and compare the results with the group sequential method. The robustness of the test is evaluated using computer simulation.
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Authors who are presenting talks have a * after their name.
