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Activity Number: 531 - Precision Medicine: Methods, Tools, and Applications
Type: Invited
Date/Time: Thursday, August 11, 2022 : 10:30 AM to 12:20 PM
Sponsor: Biometrics Section
Abstract #320321
Title: New Statistical Learning Methods for Evaluating Personalized Health Care Decision Rules
Author(s): Lu Wang*
Companies: University of Michigan
Keywords: Personalized Medicine; Dynamic Treatment Regimes; Adaptive Contrast Weighted Learning; Tree-based Reinforcement Learning (T-RL); Doubly Robust; Stochastic-Tree Search

In this talk, we present recent advances and statistical developments for evaluating Dynamic Treatment Regimes (DTR), which allow the treatment to be dynamically tailored according to evolving subject-level data. Identification of an optimal DTR is a key component for precision medicine and personalized health care. We will first present adaptive contrast weighted learning (ACWL), which combines doubly robust semiparametric regression estimators with flexible machine learning methods. We will further develop a tree-based doubly robust reinforcement learning (T-RL) method, which builds an unsupervised decision tree that maintains the nature of batch-mode reinforcement learning. Unlike ACWL, T-RL handles the optimization problem with multiple treatment comparisons directly through a purity measure constructed with augmented inverse probability weighted estimators. At the end of the talk, we will also present a new Stochastic-Tree Search method called ST-RL for evaluating optimal DTRs, which contributes to the existing literature in its non-greedy policy search and demonstrates outstanding performances even with a large number of covariates.

Authors who are presenting talks have a * after their name.

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