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Activity Number: 418 - COPSS Distinguished Achievement Award and Lecture
Type: Invited
Date/Time: Wednesday, August 5, 2020 : 3:00 PM to 4:50 PM
Sponsor: Committee of Presidents of Statistical Societies
Abstract #314085
Title: Statistics and Genetics Offer a Window into Autism
Author(s): Kathryn Roeder*
Companies: Carnegie Mellon University
Keywords:
Abstract:

A large number of genes have recently been implicated in risk for autism and these discoveries serve as a springboard for additional explorations into the neurobiology of the disorder. Quantification of gene expression, by sequencing RNA from either single cells or bulk tissue of brain, can be a critical step in such investigations. Each technology, however, brings analytical challenges. We address these challenges with novel statistical tools, including constructing a coherent hierarchical tree of cell types; novel nonparametric approaches to estimate cell-specific gene-gene networks; identification of critical marker genes using sparsity; and deconvolution to estimate subject and cell-type-specific gene expression.


Authors who are presenting talks have a * after their name.

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