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Activity Number: 540 - Statistical Methods for Adolescent HIV Trials
Type: Topic Contributed
Date/Time: Thursday, August 6, 2020 : 1:00 PM to 2:50 PM
Sponsor: Biometrics Section
Abstract #312811
Title: Design and Analysis Considerations for a Sequentially Randomized HIV Prevention Trial
Author(s): David Benkeser* and Keith Horvath and Cathy J Reback and Joshua Rusow and Michael Hudgens
Companies: Emory University and University of California, San Diego and Friends Research Institute and Friends Research Institute and UNC
Keywords: HIV prevention; SMART trial; targeted learning; causal inference; mobile health

TechStep is a randomized trial of a mobile health intervention targeted towards transgender adolescents. The interventions include an automated short messaging system, a mobile-optimized web application with social networking components, and personalized electronic counseling. The outcomes are PrEP uptake/adherence and self-reported sexual risk behaviors. The trial will be sequentially randomized in order to evaluate the efficacy of several different combinations of mHealth interventions. In this talk, I will discuss the motivation for this design, the complications in planning and analysis induced by the design, and some methods for providing robust analysis of the trial data.

Authors who are presenting talks have a * after their name.

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