Enriched Approaches for Deriving Biomarkers from Multiple Platform Data

• Activity Number: 446 - High-Dimensional Biomarkers in Drug Discovery and Early Drug Development Studies: An Integrated Data Analysis Approach
• Type: Topic Contributed
• Date/Time: Thursday, August 6, 2020 : 10:00 AM to 11:50 AM
• Sponsor: Biopharmaceutical Section
• Author(s): Dhammika Amaratunga*
• Companies: -
• Keywords: high dimensional data; biomarkers; gene expression; bioassay; fingerprint; data integration

Abstract

Enrichment, the use of a weights-based system to highlight key aspects of a dataset, can be used together with bagging to enhance the performance of biomarker detection. This will be investigated in the context of a dataset which consists of data on compound fingerprints, gene expression and bioassays.