Multicategory Angle-Based Learning for Estimating Optimal Dynamic Treatment Regimes with Censored Data

• Activity Number: 483 - Statistical Approaches in Precision Medicine
• Type: Contributed
• Date/Time: Thursday, August 6, 2020 : 10:00 AM to 2:00 PM
• Sponsor: Biometrics Section
• Author(s): Fei Xue* and Yanqing Zhang and Wenzhuo Zhou and Haoda Fu and Annie Qu
• Companies: and Yunnan University and University of Illinois at Urbana-Champaign and Eli Lilly and Company and University of California Irvine
• Keywords: Classification; Inverse probability weighting; Kaplan-Meier estimator; Outcome weighted learning; Precision medicine; Survival function

Abstract

An optimal dynamic treatment regime (DTR) consists of a sequence of decision rules in maximizing long-term benefits, which is applicable for chronic diseases such as HIV infection or cancer. In this paper, we develop a novel angle-based approach to search the optimal DTR under a multicategory treatment framework for survival data. The proposed method targets maximization the conditional survival function of patients following a DTR. In contrast to most existing approaches which are designed to maximize the expected survival time under a binary treatment framework, the proposed method solves the multicategory treatment problem given multiple stages for censored data. Specifically, the proposed method obtains the optimal DTR via integrating estimations of decision rules at multiple stages into a single multicategory classification algorithm without imposing additional constraints, which is also more computationally efficient and robust. In theory, we establish Fisher consistency of the proposed method under regularity conditions. Our numerical studies show that the proposed method outperforms competing methods in terms of maximizing the conditional survival function.