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Activity Number:
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61
- Approaches for Modeling Clustered and Longitudinal Data
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Type:
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Contributed
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Date/Time:
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Monday, August 3, 2020 : 10:00 AM to 2:00 PM
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Sponsor:
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Biometrics Section
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Abstract #312213
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Title:
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Association of Mitochondrial Haplogroups with the Risk of Alzheimer Disease
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Author(s):
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Palash Sharma* and Dongwei Hui and Jonathan Mahnken and Mary Michaelis and Elias Michaelis and Russell Swerdlow and Prabhakar Chalise
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Companies:
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University of Kansas Medical Center and Higuchi Biosciences Center, University of Kansas and Department of Biostatistics and Data Science, The University of Kansas Medical Center and Higuchi Biosciences Center, University of Kansas and Higuchi Biosciences Center, University of Kansas and Department of Neurology, University of Kansas-Medical Center and Department of Biostatistics and Data Science, University of Kansas Medical Center
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Keywords:
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Alzheimer;
Disease;
Haplogroup;
KUADC
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Abstract:
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Alzheimer’s disease (AD) is a complex form of irreversible, progressive neurodegenerative disorder. Several studies have suggested that genetics and environmental factors potentially play a significant role in the disease pathogenesis of AD. Since mitochondrial DNA is maternally inherited and variation acquired through haplogroups, we carried out a cross-sectional study of which haplogroups are potential risk factors for AD using the dataset obtained from the AD cohort. We have conducted a comprehensive study using the University of Kansas Alzheimer’s Disease Center (KU ADC) and Alzheimer’s Disease Neuroimaging Initiative (ADNI) data. The KU ADC data consisted of 146 AD and 265 control subjects, and ADNI data had 244 AD and 242 control subjects. Our studies showed that haplogroup J was found to be associated with the increased risk of AD (OR=1.87, p-value=0.0063) while haplogroup K was found to be associated with decreased risk of AD (OR=0.49,p-value=0.0102). Furthermore, APOE ?4 was significantly associated with the progression of AD (p-value = 1.9×10-11) and the association varied by haplogroups (i.e. interaction).
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Authors who are presenting talks have a * after their name.
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