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Activity Number: 27 - Innovative Methods for Missing Data and Measurement Error in Health Research
Type: Topic Contributed
Date/Time: Monday, August 3, 2020 : 10:00 AM to 11:50 AM
Sponsor: Health Policy Statistics Section
Abstract #309633
Title: Examination of Missingness, Differential Reporting and Dropout When Patients Know Their Treatment Assignment in RCTs
Author(s): Jessica Roydhouse*
Companies: Menzies Institute for Medical Research, University of Tasmania
Keywords: blinding; trial; patient-reported outcome

Blinding is a core component of trial design, however in many cases blinding may be infeasible or unethical. There is concern that lack of blinding may affect trial participants and bias results, either through patient non-completion of assessments or dropout, or that patients may report different answers after knowing their treatment assignment. Drawing on recent research using FDA trial data, we examine the potential mechanisms by which patient knowledge of treatment assignment may affect patient behavior in trials, and explore causal inference methods such as principal stratification and propensity scores for answering these questions.

Authors who are presenting talks have a * after their name.

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