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Activity Number: 263 - Addressing Incomplete Data in Public Health Studies: New Frontiers for Network-Based Studies and Meta-Analyses
Type: Topic Contributed
Date/Time: Tuesday, August 4, 2020 : 1:00 PM to 2:50 PM
Sponsor: ENAR
Abstract #309619
Title: Estimation in the Semiparametric Accelerated Failure Time Model with Missing Covariates: Improving Efficiency Through Augmentation
Author(s): Jon Steingrimsson* and Robert L Strawderman
Companies: Brown University and University of Rochester
Keywords: Survival analysis; Missing data; Augmentation; Semi-parametric; Accelerated failure time model; Two-phase sampling
Abstract:

In this talk we focus on linear regression with missing covariates and a right censored outcome. We consider a general two-phase outcome sampling design, where full covariate information is only ascertained for subjects in phase two and sampling occurs under an independent Bernoulli sampling scheme with known subject-specific sampling probabilities that depend on phase one information (e.g., survival time, failure status, and covariates). We introduce a class of augmented estimators that is shown to improve asymptotic efficiency over simple but inefficient inverse probability of sampling weighted estimators. We provide asymptotic results for the augmented estimators, and evaluate finite sample performance using simulations and data from the National Wilm's Tumor Study.


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