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Activity Number: 555 - New Statistical Methods for Microbiome Data Analysis
Type: Invited
Date/Time: Thursday, August 6, 2020 : 3:00 PM to 4:50 PM
Sponsor: ENAR
Abstract #309541
Title: Bayesian Multinomial Logistic Normal Models Through Marginally Latent Matrix-T Processes
Author(s): Sayan Mukherjee and Kimberly Roche*
Companies: Duke University and Duke University

Bayesian multinomial logistic-normal (MLN) models are popular for the analysis of sequence count data (e.g., microbiome or gene expression data) due to their ability to model multivariate count data with complex covariance structure. However, existing implementations of MLN models are limited to handling small data sets due to the non-conjugacy of the multinomial and logistic-normal distributions. We introduce MLN models which can be written as marginally latent matrix-t process (LTP) models. Marginally LTP models describe a flexible class of generalized linear regression, non-linear regression, and time series models. We develop inference schemes for Marginally LTP models and, through application to MLN models, demonstrate that our inference schemes are both highly accurate and often 4-5 orders of magnitude faster than MCMC.

Authors who are presenting talks have a * after their name.

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