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Activity Number: 60 - Statistical Analysis of Massive Neuronal Data Sets
Type: Topic Contributed
Date/Time: Sunday, July 28, 2019 : 4:00 PM to 5:50 PM
Sponsor: ENAR
Abstract #307961
Title: Neuronal Functional Connectivity Graph Estimation from Nonsimultaneous Recordings
Author(s): Giuseppe Vinci* and Gautam Dasarathy and Genevera Allen
Companies: Rice University and Arizona State University and Rice University
Keywords: graphical model; nonsimultaneous recordings; neuroscience; calcium imaging; high-dimensions; sparsity

We investigate the problem of conditional dependence graph estimation when several pairs of variables are never observed jointly, for which even the simplest metric of covariability, the sample covariance, is unavailable. This problem arises, for instance, in calcium imaging where the activities of a large population of neurons are typically observed by recording from smaller subsets of cells at once. In the Gaussian graphical model setting, the unavailability of parts of the covariance matrix translates into the unidentifiability of the precision matrix, which specifies the graph, unless additional assumptions are made. We call this problem "graph quilting" problem. We demonstrate that, under mild conditions, it is possible to correctly identify not only the edges connecting the observed pairs of nodes, but also a superset of those connecting the variables that are never observed jointly. We propose an L1 regularized graph estimator based on a partially observed sample covariance matrix and derive its rates of convergence in high-dimensions. We finally present a simulation study and the analysis of calcium imaging data from mouse visual cortex.

Authors who are presenting talks have a * after their name.

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