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Activity Number:
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343
- Innovative Trial Designs and Analytics
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Type:
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Contributed
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Date/Time:
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Tuesday, July 30, 2019 : 10:30 AM to 12:20 PM
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Sponsor:
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Biopharmaceutical Section
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Abstract #307336
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Title:
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Platform Trial Design with Incorporating Historical Data Dynamically
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Author(s):
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Weichao Bao* and Ohad Amit and Sofia Paul and Teri Ashton and Karrie Wang and Leah Suttner
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Companies:
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GlaxoSmithKline and GlaxoSmithKline and GlaxoSmithKline and GlaxoSmithKline and GlaxoSmithKline and GlaxoSmithKline
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Keywords:
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Platform trial;
mixture prior
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Abstract:
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Platform trial designs are becoming more and more popular in drug development to select the most active monotherapy or combination therapies and to enable accelerated drug development. New investigational arm(s) can be added, halted or graduated from study seamlessly. Patients enrolled to the control arm at different time points or data from other studies can as non-contemporaneous control data. This presentation will give an example to use a robust mixture prior approach to combine non-contemporaneous control with contemporaneous control dynamically.
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Authors who are presenting talks have a * after their name.
