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Activity Number:
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459
- Rethinking Intercurrent Events and Estimators Within the ICH E9(R1) Estimand Framework
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Type:
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Topic Contributed
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Date/Time:
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Wednesday, July 31, 2019 : 8:30 AM to 10:20 AM
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Sponsor:
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Biopharmaceutical Section
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Abstract #307217
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Presentation
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Title:
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Comparison of Assumptions Required for Estimating Different Parameters in the Presence of Intercurrent Events
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Author(s):
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Michael Rosenblum*
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Companies:
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Johns Hopkins Bloomberg School of Public Health
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Keywords:
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clinical trial;
missing data;
causal inference;
efficacy
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Abstract:
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We compare the different sets of assumptions required to identify and to estimate the five types of parameters defined in the recent International Council for Harmonization (ICH) E9 (R1) draft addendum on defining estimands and sensitivity analyses in clinical trials. We illustrate using a completed trial dataset from a phase 3 trial of a treatment to prevent progression to Alzheimer’s disease.
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Authors who are presenting talks have a * after their name.
