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Activity Number:
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610
- Power, Sample Size, and Applications to Time-To-Event
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Type:
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Contributed
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Date/Time:
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Thursday, August 1, 2019 : 8:30 AM to 10:20 AM
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Sponsor:
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Biopharmaceutical Section
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Abstract #307046
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Title:
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Power Calculations for Common, Nonparametric Tests in Survival
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Author(s):
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Godwin Yung* and Yi Liu
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Companies:
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Takeda Pharmaceuticals and Nektar Therapeutics
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Keywords:
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asymptotic theory;
clinical trial;
kaplan-meier;
weighted log-rank test
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Abstract:
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Large-sample distributions and their corresponding power and sample size equations are derived for common, nonparametric test statistics in survival analysis. Accrual, survival, and censoring assumptions are flexible, making the present theory useful for designing clinical trials under non-proportional hazards. We illustrate the application of our theory with a real oncology clinical trial.
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Authors who are presenting talks have a * after their name.
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