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Activity Number: 31 - Personalized/Precision Medicine II
Type: Contributed
Date/Time: Sunday, July 28, 2019 : 2:00 PM to 3:50 PM
Sponsor: Biometrics Section
Abstract #306553
Title: Inference on the Best Selected Subgroup
Author(s): Xinzhou Guo* and Xuming He
Companies: University of Michigan and University of Michigan
Keywords: Subgroup analysis; Bias correction; Sharp inference; Bootstrap

In subgroup analysis, it is widely recognized that, when a seemingly promising subgroup is selected post hoc, the traditional analysis simply based on the observed effect size and the unadjusted $p$-value of the selected subgroup is overly optimistic. In this paper, we address the issue of bias in subgroup pursuit and propose a bootstrap-based inference procedure for the best selected subgroup effect. We develop a bias-reduced estimate and valid confidence interval on the selected subgroup effect. The proposed procedure is model-free, easy to compute, and asymptotically sharp. We demonstrate the merit of the proposed procedure by working with data from MONET1 study, and show that it can help make a better-informed decision on subgroup pursuit in clinical trials.

Authors who are presenting talks have a * after their name.

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