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Abstract:
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Number needed to treat (NNT) is a clinically useful measure of treatment effect proposed by Laupacis et al in 1998 in NEJM. It is simple, intuitive and interpretable to general audience, particularly in clinical practice. However, there are some controversies around NNT and its use. In addition, NNT is defined for a binary variable only, which limits its broad application. In this presentation, we will first review and discuss issues with NNT, and we will then extend the NNT to survival endpoints using an additive hazards model. We will further propose an extension of NNT to any general distribution including continuous, categorical, and survival data. Examples and applications to real data will also be presented.
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