Long-Term Prognostic Value of Coronary Computed Tomography angiography

• Activity Number: 516 - Case Studies of Scalar-On-Image Regression
• Type: Contributed
• Date/Time: Wednesday, July 31, 2019 : 10:30 AM to 12:20 PM
• Sponsor: Section on Statistics in Imaging
• Author(s): Alomgir Hossain* and Benjamin Chow
• Companies: University of Ottawa Heart Institute and University of Ottawa Heart Institute
• Keywords: Coronary Computed Tomography Angiography; Cardiac Death; major adverse cardiac event; Propensity score; Cox regression ; administrative database

Abstract

Objective: We sought to determine the prognostic and incremental value of CAD severity, coronary atherosclerosis and left ventricular ejection fraction (LVEF) measured with CTA. Background: Computed tomographic coronary angiography (CTA) is an emerging tool used for the detection of obstructive coronary artery disease (CAD). However there is limited data supporting the prognostic value of 64-slice CTA and its ability to predict all-cause mortality and major adverse cardiac events (MACE) such as cardiac death and non-fatal myocardial infarction (MI). Methods: Between February 2006 and February 2018, 12,423 consecutive patients were prospectively enrolled and followed for a mean of 12 years. Consecutive patients (without history of revascularization, cardiac transplantation and congenital heart disease) were prospectively enrolled. Patients living in Ontario were also followed using the Institute for Clinical Evaluative Sciences (ICES) and Government of Ontario administrative database. Each CTA was evaluated for CAD severity, total plaque score (TPS) and LVEF. Patients were followed and all events were confirmed with death certificates, hospital or physician records. Statistical an