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Activity Number: 359 - Contributed Poster Presentations: Section on Medical Devices and Diagnostics
Type: Contributed
Date/Time: Tuesday, July 30, 2019 : 10:30 AM to 12:20 PM
Sponsor: Section on Medical Devices and Diagnostics
Abstract #304885
Title: ROC and C: Time-Dependent Relationships Between ROC Curve Methods and Concordance Measures
Author(s): Norberto Pantoja Galicia* and Rebecca Betensky
Companies: U.S. Food and Drug Administration and NYU
Keywords: sensitivity and specificity; C-index; censored failure times; time-dependent; ROC AUC

The traditional ROC curve depicts the sensitivity versus 1-specificity over a set of thresholds. A global scalar summary of this curve is given by the area under the ROC curve (AUC). In the context of time-dependent ROC curve methods, we are interested in global scalar measures that summarize sequences of time-dependent AUCs over time. Suitable candidates for that purpose are concordance probabilities which are measures of the predictive accuracy of a marker for an event, which occurs at random times and may be right censored. We review various notions of time dependent sensitivity and specificity and investigate the connection between these notions and different concordance measures. We explore the relationship between such measures and their corresponding AUC, and present an application.

Authors who are presenting talks have a * after their name.

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