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Activity Number: 31 - Personalized/Precision Medicine II
Type: Contributed
Date/Time: Sunday, July 28, 2019 : 2:00 PM to 3:50 PM
Sponsor: Biometrics Section
Abstract #304823 Presentation
Title: A Fully Robust Procedure for Subgroup Inference
Author(s): Ao Yuan* and Anqi Yin and Ming T Tan
Companies: and Georgetown University and Georgetown University
Keywords: Causal effect; clinical trial; doubly robust; semiparametric model; sub-group
Abstract:

In subgroup analysis of clinical trials and precision medicine, it is important to assess the causal effect of a new treatment against an existing one, and classify the new treatment favorable subgroup if it exists. As the original randomization does not apply to comparisons between subgroups, to get unbiased estimate the causal inference method will be used, in particular the doubly robust procedure, in which a propensity score model and a regression model need to be specified. As long as one of the models is correctly specified, the causal effect will be estimated unbiasedly. However, it is known that any subjectively specified model more or less deviates from the true one, and so the doubly robust procedure may still not be robust. To overcome this issue, we apply a recently proposed method to allow identification of subgroups and causal inference in subgroups. The model is a semiparametric fully robust procedure, in which both the propensity score model and the regression model are semiparametric, with monotone constraint on the nonparametric parts. Simulation studies are conducted to evaluate the performance of the proposed method and compare some existing methods. Then the


Authors who are presenting talks have a * after their name.

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