Online Program Home
My Program

Abstract Details

Activity Number: 527 - Contributed Poster Presentations: Section on Statistics in Genomics and Genetics
Type: Contributed
Date/Time: Wednesday, July 31, 2019 : 10:30 AM to 12:20 PM
Sponsor: Section on Statistics in Genomics and Genetics
Abstract #304584
Title: Detection of Inversely Enriched Pathways in PBMC Cells in Alzheimer’s Disease and Cancer
Author(s): Lisa Neums* and Jeffrey A. Thompson
Companies: University of Kansas Medical Center and University of Kansas Medical Center
Keywords: Alzheimer's disease; cancer; inverse comorbidity; pbmc

A growing number of epidemiological studies confirm the existence of direct and inverse comorbidities between different Alzheimer’s disease (AD) types and certain cancers. Inverse comorbidities such as these provide an ideal opportunity to identify the mechanisms through which protection against both diseases might be conferred and exploited. A number of factors are generally considered to impact comorbidities, such as age, lifetime exposures, and socio-economic factors, but none yet have been found to play a role in cancer and AD comorbidity. Thus, overlapping genetic and molecular mechanisms hold the greatest promise in explaining relationships between these diseases. In this work, we demonstrate using statistical omics that inverse patterns of disrupted gene expression, associated with cellular metabolism and associated with inverse comorbidity, are detectable in the blood of cancer and Alzheimer’s patients. However, this is the first time these changes have been demonstrated to be detectable outside of the disease tissues. This suggests the possibility of blood markers that can identify certain individuals with reduced or increased risk for either disease.

Authors who are presenting talks have a * after their name.

Back to the full JSM 2019 program