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Activity Number: 73 - Alternative Designs and Related Topics
Type: Contributed
Date/Time: Sunday, July 28, 2019 : 4:00 PM to 5:50 PM
Sponsor: Biopharmaceutical Section
Abstract #304544 Presentation
Title: The Performance of Largest Caliper Matching: An Application to SUPPORT Data
Author(s): Sharif Mahmood*
Keywords: Matching; Covariate balance; Treatment Effect; Largest Caliper Matching; MCMC Simulation; Right Heart Catheterization

The paper presents a reinvestigation of the effect of right heart catheter to critically ill patients using different matching methods. To estimate the effect efficiently—the study proposed a new method which is computationally efficient and convenient in implication—largest caliper matching and compared the performance with other five popular matching methods by simulation. The bias, empirical standard deviation and the mean square error of the estimates in the simulation are checked under different treatment prevalence and different distributions of covariates. A Monte Carlo simulation is employed to measure the performance of these methods. It is shown that matched samples improve estimation of the population treatment effect in a wide range of settings. It reduces bias if the data contains the selection on observables and treatment imbalances. Also, findings about the relative performance of the different matching methods are provided to help practitioners determine which method should be used under certain situations. Beside making the comparisons among several matching methods for right heart catheterization (RHC), important demographic and socioeconomic factors are reported.

Authors who are presenting talks have a * after their name.

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