Estimating Additive Interaction Effect in Stratified Two-Phase Case-Control Design

• Activity Number: 156 - Statistical Interactions – Making an Impact in Health Science
• Type: Topic Contributed
• Date/Time: Monday, July 29, 2019 : 10:30 AM to 12:20 PM
• Sponsor: Section on Risk Analysis
• Author(s): Ai Ni* and Jaya M Satagopan
• Companies: The Ohio State University and Memorial Sloan Kettering Cancer Center
• Keywords: Additive interaction; Inverse-probability weighting; Multiple imputation; Offset; Stratified two-phase case-control design

Abstract

There is considerable interest in epidemiology to estimate an additive interaction effect between two risk factors in case-control studies. An additive interaction is defined as the differential reduction in absolute risk associated with one factor between different levels of the other factor. A stratified case-control design is commonly used in epidemiology to reduce the cost of assembling covariates. It is crucial to obtain valid estimates of the model parameters by accounting for the underlying stratification scheme to obtain accurate and precise estimates of additive interaction effects. The aim of this study is to examine the properties of different methods for estimating model parameters and additive interaction effects under a stratified case-control design. Using simulations, we investigate the properties of three existing methods, namely stratum-specific offset, inverse-probably weighting, and multiple imputation for estimating model parameters and additive interaction effects. We also illustrate these properties using data from two published epidemiology studies.