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Activity Number: 653 - Machine Learning and Other Statistical Methods in Clinical Trials
Type: Contributed
Date/Time: Thursday, August 1, 2019 : 10:30 AM to 12:20 PM
Sponsor: Biopharmaceutical Section
Abstract #304292 Presentation
Title: Deep Neural Networks for Survival Analysis Using Pseudo Values
Author(s): Dai Feng* and Lili Zhao
Companies: AbbVie and University of Michigan
Keywords: survival analysis; pseudo values; deep neural network; Bayesian deep neural network
Abstract:

There has been increasing interest in modelling survival data using deep learning methods in medical research. Current approaches have focused on designing special cost functions to handle censored survival data. We propose a very different method with two steps. In the first step, we transform each subject's survival time into a series of pseudo conditional survival probabilities. In the second step, we use these pseudo probabilities as quantitative response variable in a deep neural network (DNN) model. By using the pseudo values, we reduce a complex survival analysis to a standard regression problem, which greatly simplifies the neural network construction. Furthermore, we investigate the corresponding Bayesian DNN model and using variational inference to conduct inference for various quantities of interest.


Authors who are presenting talks have a * after their name.

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