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Activity Number:
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498
- Designs and Statistical Methods Used in Genetics and Mental Health for Army Study to Assess Risk and Resilience in Servicemembers (Army STARRS)
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Type:
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Topic Contributed
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Date/Time:
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Wednesday, July 31, 2019 : 10:30 AM to 12:20 PM
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Sponsor:
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Mental Health Statistics Section
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Abstract #304275
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Presentation
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Title:
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Genome-Wide Association Studies of PTSD in 2 Cohorts of US Army Soldiers
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Author(s):
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Steven Heeringa*
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Companies:
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University of Michigan Institute for Social Research
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Keywords:
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Genome-wide Association;
Genetic;
Trauma;
Military;
PTSD;
Post-traumatic Stress
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Abstract:
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Posttraumatic stress disorder (PTSD) is a prevalent, serious public health concern, particularly in the military. The objective of this study was to discover genetic loci associated with lifetime risk of PTSD in two US Army cohorts from the Army Study of Risk and Resilience in Servicemembers (Army STARRS) and replicate findings in independent samples. Data were obtained in two coordinated genome-wide association studies of mental health in the US military. GWAS results were meta-analyzed within ancestral groups across studies and finally across ancestral groups and studies. A genome-wide significant locus for PTSD was identified in one of the two African American samples. Cross-phenotype polygenic score analyses suggest shared genetic risk between PTSD and major depressive disorder and attention-deficit hyperactivity disorder. This presentation is based on research previously described in Stein et al. (2016). Army study to assess resilience in servicemembers: GWAS of Posttraumatic Stress Disorder in 2 Cohorts of US Army Soldiers. JAMA Psychiatry 73(7):695–704.
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Authors who are presenting talks have a * after their name.
