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Activity Number: 118 - Emerging Challenges in Precision Medicine
Type: Topic Contributed
Date/Time: Monday, July 29, 2019 : 8:30 AM to 10:20 AM
Sponsor: Biometrics Section
Abstract #303046
Title: Sparse Learning and Structure Identification for Ultra-High-Dimensional Image-On-Scalar Regression
Author(s): Xinyi Li* and Li Wang and Huixia Judy Wang
Companies: SAMSI and Iowa State University and The George Washington University
Keywords: Bivariate splines; Imaging Data; Triangulation; Varying coefficient models

This paper considers high-dimensional image-on-scalar regression, where the spatial heterogeneity of covariate effects on imaging responses is investigated via a flexible partially linear spatially varying coefficient model. To tackle the challenges of spatial smoothing over the imaging response's complex domain consisting of regions of interest, we approximate the spatially varying coefficient functions via bivariate spline functions over triangulation. We first study estimation when the active constant coefficients and varying coefficient functions are known in advance. We then further develop a unified approach for simultaneous sparse learning (i.e., variable selection) and model structure identification (i.e., determination of spatially varying vs. constant coefficients) in the presence of ultra-high-dimensional covariates. Our method can identify zero, nonzero constant and spatially varying components correctly and efficiently. The estimators of constant coefficients and varying coefficient functions are consistent and asymptotically normal. The method is evaluated by Monte Carlo simulation studies and applied to a dataset provided by the ADNI.

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