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Activity Number: 421 - Contributed Poster Presentations: Quality and Productivity Section
Type: Contributed
Date/Time: Tuesday, July 30, 2019 : 2:00 PM to 3:50 PM
Sponsor: Quality and Productivity Section
Abstract #303003
Title: Designing Bridging Studies to Adjust for Assay Changes in National Surveys
Author(s): Maya Sternberg*
Companies: Centers for Disease Control & Prevention
Keywords: NHANES; Calibration; bridging study
Abstract:

The National Health and Nutrition Examination Survey (NHANES) is often used to monitor trends in various nutritional biomarkers. While NHANES tries to maintain the same biomarker assay over time, there are times when an assay may change. To minimize the impact these assay changes on fluctuations of a biomarker’s concentration over time, “bridging studies” have been designed to develop statistical models to facilitate trend assessment. The statistical models range from simple regression "adjustment equations" to multiple imputation models. Using a combination of simulations and real data, this paper explores the conditions under which the various statistical models may lead to reasonable statistical inferences concerning biomarker concentration trends and whether aspects of the bridging study design can mitigate the problems of the simpler statistical adjustment models.


Authors who are presenting talks have a * after their name.

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