Increases in cross-national inter-connectivity are leading to greater understanding and respect for individuals who represent diverse cultures, beliefs and historical experiences. Within this context, multinational, multiregional, and multicultural survey research, what we refer to as 3MC research, has developed in recent years. In addition to basic respect for human diversity, 3MC methods emphasize the importance and address the comparability of survey data across nations, regions and cultures. These methods represent an evolution of methodology away from opportunistic ad hoc international data collection and analysis activities towards more coordinated efforts in which the nations and cultures of interest have equal representation and share equal responsibility for study planning and leadership. In this presentation, we provide a general overview of this topic, highlight key challenges, and discuss recent developments in 3MC methodologies.