Online Program Home
My Program

Abstract Details

Activity Number: 321 - Causal Inference in Vaccine Trials and Outbreak Investigations: Epidemiologic Study Design and Statistical Analysis
Type: Invited
Date/Time: Tuesday, July 30, 2019 : 10:30 AM to 12:20 PM
Sponsor: Section on Statistics in Epidemiology
Abstract #300132
Title: Estimating Causal Effects of Vaccines Under Interference from Randomized and Partially Randomized Studies
Author(s): M Elizabeth Halloran*
Companies: University of Washington and Fred Hutchinson Cancer Research Center
Keywords: Causal ; Interference ; Vaccines; Network; Infectious disease

Here we consider estimating causal effects of vaccination under interference from studies where groups are randomized to receive a vaccine of interest or a control vaccine. Individuals within the groups self-select to participate and be vaccinated or not, thus many may not comply with the randomization. Information on disease outcome is available for all individuals in the groups. We consider estimation and inference for the indirect (spillover), total, and overall effects from such studies. We compare this to two-staged randomized studies. We present an influenza vaccine study and a typhoid vaccine study as examples.

Authors who are presenting talks have a * after their name.

Back to the full JSM 2019 program