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Activity Number: 212 - Scientifically and Clinically Motivated Statistical Methods for Human Brain Data Analysis
Type: Invited
Date/Time: Monday, July 29, 2019 : 2:00 PM to 3:50 PM
Sponsor: Section on Statistics in Imaging
Abstract #300046
Title: A Bayesian Stochastic-Blockmodel-Based Approach for Mapping Epileptic Brain Networks
Author(s): Tingting Zhang*
Companies: University of Virginia
Keywords: Brain networks; Stochastic Blockmodel; Epileptic brain

The brain regions and the influences exerted by each region over another, called directional connectivity, form a directional network. We study normal and abnormal directional brain networks of epileptic patients using their intracranial EEG (iEEG) data, which are multivariate time series recordings of many small brain regions. We propose a high-dimensional state-space multivariate autoregression model (SSMAR) for iEEG data. To characterize brain networks with a commonly reported cluster structure, we use a stochastic-block-model-motivated prior for possible network patterns in the SSMAR. We develop a Bayesian framework to estimate the proposed high-dimensional model, examine the probabilities of nonzero directional connectivity among every pair of regions, and identify clusters of densely-connected brain regions. Applying the developed SSMAR and Bayesian approach to an epileptic patient's iEEG data, we reveal the patient's network changes at the seizure onset and the unique connectivity of the seizure onset zone (SOZ), where seizures start and spread to other normal regions.

Authors who are presenting talks have a * after their name.

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