Online Program Home
My Program

Abstract Details

Activity Number: 557 - Affordable Clinical Trials Through Innovative Technology
Type: Invited
Date/Time: Wednesday, August 1, 2018 : 2:00 PM to 3:50 PM
Sponsor: Caucus for Women in Statistics
Abstract #333043
Title: Adaptive Design of Affordable Clinical Trials Using Master Protocols in the Era of Precision Medicine
Author(s): Tze Leung Lai*
Companies: Stanford University

Advances in pan-omic technologies and systems biology have led to novel therapies in the era of precision medicine. After describing the challenges in designing randomized controlled trials to evaluate these new treatments, such as recruiting patients with rare genetic subtypes of a disease and the eventual unaffordability of the treatment, we give a brief review of recent developments in master protocols for umbrella, basket, and platform trials to address these challenges. We then introduce innovative adaptive designs of basket trials, which we illustrate with a master protocol of a clinical trial to evaluate the effect of a CK2 inhibitor on four baskets of cancers involved in the hedgehog pathway for pediatric patients.

Authors who are presenting talks have a * after their name.

Back to the full JSM 2018 program