Online Program Home
My Program

Abstract Details

Activity Number: 83 - SPEED: Survival Analysis
Type: Contributed
Date/Time: Sunday, July 29, 2018 : 4:00 PM to 4:45 PM
Sponsor: Section on Statistics in Epidemiology
Abstract #332540
Title: Inference for Fine-Gray Competing Risks Model with High-Dimensional Covariates
Author(s): Jue Hou* and Jelena Bradic and Ronghui Xu
Companies: UCSD Biostatistics and UC San Diego and UC San Diego
Keywords: competing risks; high-dimensional inference; survival analysis

The purpose of this work is to construct confidence intervals for the regression coefficients in the Fine-Gray model for competing risks data with random censoring, where the number of covariates can be larger than the sample size. Despite strong motivation from biostatistics applications, highdimensional Fine-Gray model has attracted relatively little attention among the methodological or theoretical literatures. We fill in this blank by proposing first a consistent regularized estimator and then the confidence intervals based on the one-step bias-correcting estimator. We are able to generalize the partial likelihood approach for the Fine-Gray model under random censoring despite many technical difficulties. We lay down a methodological and theoretical framework for the one-step bias-correcting estimator with the partial likelihood, which does not have iid entries. We also handle for our theory the approximation error from the inverse probability weighting, proposing novel concentration results for time dependent processes. We apply the proposed methodology to a study of non-cancer mortality among prostate cancer patients using the linked Medicare-SEER data.

Authors who are presenting talks have a * after their name.

Back to the full JSM 2018 program