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Activity Number:
439 - Biopharmaceutical Section A.M. Roundtable Discussion (Added Fee)
Type: Roundtables
Date/Time: Wednesday, August 1, 2018 : 7:00 AM to 8:15 AM
Sponsor: Biopharmaceutical Section
Abstract #330943
Title: Practical Guidelines and User-Friendly Software for Bayesian Adaptive Designs
Author(s): J. Jack Lee*
Companies: Univ of Texas-M D Anderson Cancer Center
Keywords: Bayesian adaptive designs; clinical trial design; clinical trial conduct; simulations; operating characteristics; user-friendly software

Compared to the frequentist method, Bayesian approach offers many advantages as it is more intuitive, directly addressing the question of interest, properly accounting for uncertainty, allowing the incorporation of utility for decision making with multiple outcomes (e.g., efficacy and toxicity), etc. Bayesian framework is ideally suitable for adaptive designs which are more flexible and can be more efficient than the standard frequentist-based designs. In this roundtable, I will share practical guidelines for the successful implementation and introduce many useful tools for the design and conduct of Bayesian adaptive trials including downloadable programs and Shiny applications. Participants are also encouraged to share their experiences, challenges, and successful examples of applying Bayesian adaptive designs in clinical trials. Useful tools can be found at the following sites.

Authors who are presenting talks have a * after their name.

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