Activity Number:
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123
- Binary and Ordinal Outcome Regression
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Type:
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Contributed
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Date/Time:
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Monday, July 30, 2018 : 8:30 AM to 10:20 AM
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Sponsor:
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Biometrics Section
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Abstract #330897
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Presentation
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Title:
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A Bayesian Logistic Model with Covariate to Identify Optimal Dose for Heterogeneous Population in Phase I Oncology Trial
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Author(s):
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Xin Wei* and Michael Branson
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Companies:
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Celgene Corporation and celgene corporation
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Keywords:
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Oncology Clinical Trial;
dose finding;
MTD;
Bayesian Logistic Regression;
adaptive design;
CRM
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Abstract:
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Phase I oncology FIH trial aims at identifying the maximum tolerated dose (MTD) for patients that can be used in later trial. Previous work developed a Bayesian logistic model based continuous reassessment method (BLRM) that improves the precision of MTD identification. Our work demonstrates the further improvement of optimal dose finding for a heterogeneous population by modeling the patient risk factor as covariate. In addition, we use simulation to show that the non-parsimonious model does not compromise the ability of model to pick the MTD and other operating characteristics in the context of 3-parameter logistic regression for dose/toxicity relationship.
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Authors who are presenting talks have a * after their name.