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Activity Number:
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178
- Statistical Methods for Analysis of Heterogeneous Tissue Samples in Bulk and Single-Cell Sequencing Data
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Type:
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Contributed
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Date/Time:
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Monday, July 30, 2018 : 10:30 AM to 12:20 PM
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Sponsor:
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Section on Statistics in Genomics and Genetics
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Abstract #330834
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Presentation
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Title:
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Estimating Tumor Fraction in Circulating Cell-Free DNA Using Shallow Whole Genome Sequencing
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Author(s):
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Venkatraman Seshan* and Nicholas Socci and Dana Tsui and Julie Yang
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Companies:
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MSKCC and MSKCC and MSKCC and MSKCC
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Keywords:
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DNA;
copy number;
cancer
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Abstract:
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Cell-free plasma DNA (cfDNA) is defined as fragments of DNA present in the extracellular fluid. These DNA fragments are mostly derived from cells that underwent apoptosis. In a subject with cancer, cfDNA are derived from both normal and tumor cells and thus it will reflect somatic changes present in the tumor DNA. In this talk we will present an adaptation of the circular binary segmentation algorithm for the analysis of copy number information in cfDNA and use it to estimate a cancer cell fraction in cfDNA.
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Authors who are presenting talks have a * after their name.
