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Activity Number: 583 - Statistical Methods in Health Services and Performance Profiling
Type: Contributed
Date/Time: Wednesday, August 1, 2018 : 2:00 PM to 3:50 PM
Sponsor: Health Policy Statistics Section
Abstract #330585
Title: Network Meta-Analysis for N-Of-1 Trials with Ordinal Outcomes
Author(s): Youdan Wang* and Christopher Schmid
Companies: Brown University and Brown University
Keywords: Network meta-analysis; N-of-1; Bayesian hierarchical model; Direct and indirect evidence; ordinal data

N-of-1 trials are single-patient multiple-crossover studies for determining the relative effectiveness of treatments for an individual participant. Although N-of-1 trials are designed to estimate treatment efficacy in single patients, N-of-1 trials assessing the same scientific questions may be combined together and analyzed with a multilevel model so that in aggregate they increase the information about each patient by borrowing of strength. When the treatments compared differ between trials, it may be possible to construct a network of treatments and use network meta-analysis methods to make comparisons among the treatments both at the individual and population levels. Ordinal outcomes are very common in clinical trials as well as in social science research. We develop network analytical models for the ordinal outcomes and will compare results with those from analyses of individual data alone. We will use data from a series of N-of-1 trials assessing different treatments for chronic pain to demonstrate the application of hierarchical models for N-of-1 ordinal data.

Authors who are presenting talks have a * after their name.

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