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Activity Number: 656 - Subgroup Evaluations in Advancing Drug Development
Type: Topic Contributed
Date/Time: Thursday, August 2, 2018 : 10:30 AM to 12:20 PM
Sponsor: Biopharmaceutical Section
Abstract #329785
Title: Using Hierarchical Models to Estimate Subgroup Effects in a Clinical Trial
Author(s): Anna McGlothlin*
Companies: Berry Consultants
Keywords: hierarchical model; Bayesian

Assessing heterogeneity of a drug's treatment effect across patient subgroups is an important aspect of understanding the benefit of a new therapy. Bayesian hierarchical models are particularly well-suited to estimation of these subgroup effects. In this talk, we present an example using a hierarchical model within an adaptive design to evaluate subgroup-specific decision rules.

Authors who are presenting talks have a * after their name.

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