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Activity Number:
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656
- Subgroup Evaluations in Advancing Drug Development
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Type:
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Topic Contributed
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Date/Time:
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Thursday, August 2, 2018 : 10:30 AM to 12:20 PM
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Sponsor:
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Biopharmaceutical Section
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Abstract #329785
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Title:
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Using Hierarchical Models to Estimate Subgroup Effects in a Clinical Trial
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Author(s):
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Anna McGlothlin*
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Companies:
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Berry Consultants
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Keywords:
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hierarchical model;
Bayesian
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Abstract:
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Assessing heterogeneity of a drug's treatment effect across patient subgroups is an important aspect of understanding the benefit of a new therapy. Bayesian hierarchical models are particularly well-suited to estimation of these subgroup effects. In this talk, we present an example using a hierarchical model within an adaptive design to evaluate subgroup-specific decision rules.
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Authors who are presenting talks have a * after their name.
