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Activity Number: 617 - Indirect Comparisons of Treatment Effects for Clinical Regulatory and Health Economic Evaluations
Type: Topic Contributed
Date/Time: Thursday, August 2, 2018 : 8:30 AM to 10:20 AM
Sponsor: Biopharmaceutical Section
Abstract #329662 Presentation
Title: Uncontrolled Studies and Health Technology Appraisal ? The Need for Methods, Modeling, and Further Research
Author(s): Anthony Hatswell*
Companies: University College London
Keywords: uncontrolled study; single arm trial; health technology assessment; HTA; ICER; cost-effectiveness

In health technology appraisal modelling is commonly used, and accepted as the most appropriate approach to estimate the relative effectiveness of interventions. Beyond simply accepting modelled estimates, groups such as the National Institute for Health and Care Excellence (NICE) publish best practice guidelines for methods - including techniques for observational data such as propensity scoring and Matching Adjusted Indirect Comparison. This presentation will discuss the challenges and uncertainties in interpreting these modelled results - particularly from novel methods. There will then be a discussion of further research that is required including understanding the bias and limitations of different approaches, how to assess/synthesize multiple MAICs, and how to determine what is an appropriate cross study comparison without a common control.

Authors who are presenting talks have a * after their name.

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