Leadership is a skill that is required for success at all levels, not just for those with corner offices or with more senior level responsibilities. Every statistician, no matter the level, has the ability to lead and demonstrate leadership every day. As the second talk of this leadership series, this presentation covers the topic on effective leadership at the level of program lead statistician. I will share the best practice and lessons learned based on my past experience as the indication lead statistician of a late stage development program of immuno-oncology. This presentation consists of three parts: (1) Leading without authority - a dilemma; (2) The matrix model - challenge and opportunity; (3) Leading with style - influential leadership.